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There and back again: Translating adoptive cell therapy to canine cancer and improving human treatment
Samuel A Brill1,2, Douglas H Thamm1,2,3
1Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.
Abstract:
Adoptive cell transfer (ACT) is a burgeoning therapeutic modality within human immuno-oncology. Novel approaches towards ACT are being developed in the pre-clinical setting faster than they can be evaluated in human clinical trials. Many of the therapeutic approaches used in human medicine have already been evaluated to some degree in canine patients. While this form of immunotherapy in veterinary medicine is still in its infancy, as these approaches develop, canine ACT will become a tool for both the veterinary oncologist and the translational researcher. This review details canine ACT trials to date, with attention given to the precedents provided by human oncology.
Insights
Adoptive cell transfer (ACT) is a promising cancer immunotherapy. Canine ACT trials offer valuable insights for human immuno-oncology and veterinary medicine, bridging pre-clinical research and clinical application.
Area of Science:
- Veterinary Oncology
- Immuno-oncology
- Translational Research
Background:
- Adoptive cell transfer (ACT) is a rapidly advancing immunotherapy in human oncology.
- Pre-clinical development of novel ACT strategies often outpaces human clinical trial evaluation.
- Canine patients have historically served as valuable models for human medical treatments.
Purpose of the Study:
- To review existing canine ACT trials.
- To highlight the parallels between canine and human ACT research.
- To establish canine ACT as a translational tool for oncology.
Main Methods:
- Literature review of published canine ACT studies.
- Analysis of therapeutic approaches and outcomes in canine cancer patients.
- Comparison with established human immuno-oncology principles.
Main Results:
- Canine ACT is an emerging field with potential for therapeutic application.
- Canine studies provide a preclinical evaluation platform for novel ACT strategies.
- Established human ACT protocols inform veterinary applications.
Conclusions:
- Canine ACT research is crucial for advancing veterinary oncology.
- Canine ACT serves as a vital translational bridge between laboratory research and human clinical trials.
- The development of canine ACT benefits both veterinary patients and the broader field of immuno-oncology.
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