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Clinical Features of COVID-19 Patients With Venous Thromboembolism

Kai Liang1, Ying Fu2, Yi Kang3

  • 1Department of Vascular Surgery, 89632Henan Provincial People's Hospital, the Affiliated People's Hospital of Zhengzhou University, the Affiliated People's Hospital of Henan University, Zhengzhou, Henan, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|June 25, 2021
PubMed

Insights

Venous thromboembolism (VTE) occurred in 20% of COVID-19 patients, particularly severe and critical cases. D-dimer levels can predict prognosis and mortality risk in these patients.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Cardiology

Background:

  • Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic events.
  • Venous thromboembolism (VTE) is a serious complication that can affect COVID-19 patients, particularly those with severe symptoms.

Purpose of the Study:

  • To assess the clinical features of COVID-19 patients who develop VTE.
  • To identify risk factors and prognostic indicators for VTE in COVID-19.
  • To inform the development of preventive strategies for VTE in COVID-19 cases.

Main Methods:

  • Retrospective analysis of COVID-19 patients admitted to Henan Provincial People's Hospital.
  • Inclusion of patients with mild to moderate, severe, and critical symptoms.
  • Analysis of VTE incidence, demographic data, laboratory parameters (including D-dimer and platelet counts), and patient outcomes.

Main Results:

  • Overall VTE incidence was 20.0% among the 35 analyzed COVID-19 patients.
  • VTE occurred predominantly in severe (1 case) and critical (6 cases) COVID-19 patients.
  • Elevated D-dimer levels were statistically significant, serving as both a diagnostic and prognostic indicator for VTE in COVID-19.
  • Severe and critical cases showed reduced platelet counts, indicating a risk of hemorrhage.
  • A significant increase in D-dimer was associated with a higher risk of death in critical COVID-19 cases.

Conclusions:

  • VTE is a significant complication in COVID-19, particularly in severe and critical cases.
  • D-dimer is a crucial marker for risk assessment and prognosis in COVID-19 patients with VTE.
  • Clinical management should balance the risks of hemorrhage and thrombosis during treatment for COVID-19.

Keywords:
COVID-19incidencepneumoniavenous thromboembolism

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