Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases

Area of Science:

• Microbiology
• Cardiology
• Genomics

Background:

• Cardiovascular diseases (CVDs) are a leading cause of global mortality.
• The complex pathogenesis of CVDs is not fully understood.
• Growing evidence suggests a role for the gut microbiome and its metabolites in CVD development.

Purpose of the Study:

• To review meta-omics approaches for studying the gut microbiome in CVDs.
• To highlight current applications of these techniques in cardiovascular research.
• To identify potential cardiovascular risk biomarkers and therapeutic targets.

Main Methods:

• Utilizing next-generation sequencing and computational strategies.
• Employing parallel meta-omics approaches (genomics, transcriptomics, proteomics, metabolomics).
• Conducting culture-independent microbial investigations.

Main Results:

• Meta-omics enables comprehensive analysis of the gut microbiome's role in CVDs.
• These approaches provide insights into multifactorial CVD pathogenesis.
• Identified links between gut microbial alterations and conditions like atherosclerosis and hypertension.

Conclusions:

• Meta-omics pipelines offer powerful tools for cardiovascular research.
• Understanding the gut microbiome is crucial for addressing knowledge gaps in CVDs.
• This field holds promise for novel cardiovascular risk biomarkers and therapeutic interventions.