Related Experiment Video

Updated: Nov 1, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

Sunil K Joshi1, Tamilla Nechiporuk2, Daniel Bottomly3

  • 1Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA; Department of Physiology & Pharmacology, School of Medicine, Oregon Health & Science University, Portland, OR, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR, USA.

Cancer Cell
|June 25, 2021
PubMed
Summary

Gilteritinib resistance in FLT3-mutated acute myeloid leukemia (AML) evolves in stages. Early resistance involves the bone marrow microenvironment, while late resistance stems from intrinsic cell changes and NRAS mutations. Targeting Aurora kinase B (AURKB) with gilteritinib may overcome resistance.

Keywords:
AMLAurora kinase BFLT3NRASdrug resistancegilteritiniblipid metabolismquizartinibtumor microenvironmenttyrosine kinase inhibitor

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