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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

Updated: Nov 1, 2025

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
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Understanding Skin Failure: A Scoping Review.

Lizanne Dalgleish1, Jill Campbell, Kathleen Finlayson

  • 1At the School of Nursing, Queensland University of Technology, Brisbane, Australia, Lizanne Dalgleish, PhD, RN, is PhD Candidate; Jill Campbell, PhD, RN, is Senior Research Fellow; Kathleen Finlayson, PhD, RN, is Lecturer; Jessica Ingleman, MSN, RN, is Lecturer; Christina Parker, PhD, RN, is Senior Lecturer; and Fiona Coyer, PhD, RN, is Professor. Michelle Barakat-Johnson, PhD, RN, is Senior Lecturer, University of Sydney, Camperdown. Amy Beath, BSN, RN, is Transitional Nurse Practitioner-Wounds, Murrumbidgee Local Health District, New South Wales. The authors have disclosed no financial relationships related to this article. Submitted June 21, 2020; accepted in revised form December 1, 2020; published online ahead of print June 23, 2021.

Advances in Skin & Wound Care
|June 27, 2021
PubMed
Summary
This summary is machine-generated.

The term "skin failure" is increasingly used, but lacks a clear definition and empirical evidence. Further research is urgently needed to establish a global understanding of skin failure causes and definitions.

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Area of Science:

  • Dermatology
  • Healthcare Research
  • Medical Literature Analysis

Background:

  • The term "skin failure" is increasingly prevalent in medical literature.
  • Understanding its usage and definition is crucial for clinical practice.

Purpose of the Study:

  • To map the literature use of "skin failure" over time.
  • To enhance the understanding of "skin failure" in clinical practice.

Main Methods:

  • Scoping review of multiple databases (PubMed, Embase, CINAHL, Google Scholar, Open Gray, ProQuest).
  • Included diverse study designs, editorials, and gray literature.
  • Extracted data on publication details, term usage, etiology, and definitions.

Main Results:

  • Identified two primary themes: etiology of skin failure and interchangeable use of definitions.
  • Significant increase in the use of "skin failure" over the past 30 years.
  • Lack of empirical evidence and divergent definitions were noted.

Conclusions:

  • There is a significant gap in empirical evidence for skin failure.
  • Divergent definitions and multiple etiological theories exist.
  • An urgent need for a globally agreed-upon definition and better understanding of skin failure etiology is highlighted.