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Updated: Nov 1, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Technological Advances in Charged-Particle Therapy.

Jong Min Park^1,2,3,4, Jung-In Kim^1,2,3, Hong-Gyun Wu^1,2,3,4

¹Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.

Cancer Research and Treatment

|June 27, 2021

Summary

This summary is machine-generated.

Charted-particle therapy (CPT) offers precise cancer treatment by targeting tumors and sparing healthy tissue. Advances in proton beam therapy (PBT) and carbon-ion radiotherapy (CIRT) enhance effectiveness and patient outcomes globally.

Keywords:

Carbon-ion radiotherapy Charged-particle therapy Proton beam therapy

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Published on: March 24, 2022

Area of Science:

Oncology
Medical Physics
Radiation Oncology

Background:

Charted-particle therapy (CPT) utilizes unique physical and biological properties to precisely deliver radiation doses to tumors while minimizing damage to surrounding healthy tissues.
Proton beam therapy (PBT) pioneered human CPT in the 1950s, followed by carbon-ion radiotherapy (CIRT) in 1977, which leverages the favorable biological characteristics of carbon ions for cancer treatment.
Carbon ions exhibit a Bragg peak coinciding with maximum relative biological effectiveness and low oxygen enhancement ratios, making CIRT a mainstream heavy-ion cancer therapy.

Purpose of the Study:

To review recent technological advancements in charted-particle therapy (CPT) that enhance its clinical application.
To highlight the evolution and current status of proton beam therapy (PBT) and carbon-ion radiotherapy (CIRT).
To underscore the ongoing global research efforts aimed at improving CPT efficacy and efficiency.

Main Methods:

Review of technological advancements in CPT, including rotating gantry systems, fast pencil-beam scanning, image-guided particle therapy, and intensity-modulated particle therapy.
Analysis of global treatment data for PBT and CIRT up to 2019.
Synthesis of current research trends in CPT development.

Main Results:

Significant technological progress has been made in CPT, enabling more sophisticated treatment delivery.
As of 2019, over 222,000 patients received PBT and over 34,000 patients received CIRT worldwide.
Ongoing research worldwide focuses on further optimizing CPT for improved cancer treatment outcomes.

Conclusions:

CPT, particularly CIRT, has become an established and effective modality in cancer treatment.
Technological innovations continue to expand the capabilities and clinical utility of CPT.
Further research and development are crucial for advancing CPT and maximizing its benefits for cancer patients.