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Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways.

Xiaohui Zhong1, Feng Zhang1,2,3, Xinyao Yin1

  • 1Wuxi School of Medicine, Jiangnan University, Wuxi 214122, P.R. China.

Journal of Microbiology and Biotechnology
|June 28, 2021
PubMed
Summary
This summary is machine-generated.

This review explores how gut microbes influence bone health through signaling pathways. Understanding this gut-bone axis offers new strategies for treating bone diseases.

Keywords:
Bone homeostasisbone metabolismgut microbiotasignaling pathway

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Area of Science:

  • Microbiology
  • Bone Biology
  • Immunology

Background:

  • The intricate relationship between gut microbiota and bone homeostasis is an emerging area of research.
  • While osteal signaling pathways are studied, the role of gut microbial-dependent pathways in metabolic and immune bone regulation remains unclear.

Purpose of the Study:

  • To review the mechanisms of microbiota-mediated gut-bone crosstalk.
  • To elucidate the signaling pathways involved in maintaining bone homeostasis.
  • To explore the potential of dietary interventions for modulating gut microbiota to improve bone health.

Main Methods:

  • Literature review of studies on gut microbiota and bone health.
  • Analysis of direct (translocation) and indirect (metabolite) mechanisms of gut-bone communication.
  • Examination of signaling pathways including bone morphogenetic protein/SMADs, Wnt, and OPG/RANKL.

Main Results:

  • Gut microbiota influences bone homeostasis through direct and indirect signaling pathways.
  • Mechanisms involve immune responses, hormone secretion, osteoblast/osteoclast fate, and calcium absorption.
  • Dietary interventions can modulate gut microbiota to impact osteal signaling.

Conclusions:

  • A signaling network exists between the gut ecosystem and skeletal system for dynamic homeostasis.
  • Targeting gut microbiota presents a novel therapeutic strategy for bone diseases.
  • Further research into gut microbial modulation can lead to improved treatments for skeletal disorders.