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Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle

Liang Cui¹, Zhen Zhang¹, Chun-Yi Zac Lo²

¹Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Frontiers in Aging Neuroscience

|June 28, 2021

Summary

This summary is machine-generated.

Objectively-defined subtle cognitive decline (Obj-SCD) shows unique brain function changes, distinct from mild cognitive impairment (MCI). These Obj-SCD brain alterations correlate differently with cognitive performance, suggesting a distinct preclinical stage.

Keywords:

cognitive function function activity mild cognitive impairment objectively-defined subtle cognitive decline resting-state functional MRI

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Area of Science:

Neuroscience
Cognitive Science
Medical Imaging

Background:

Preclinical cognitive impairment identification is crucial for early intervention.
Objectively-defined subtle cognitive decline (Obj-SCD) is a proposed preclinical stage.
Brain function alterations in Obj-SCD require further investigation.

Purpose of the Study:

To explore brain function activity patterns in Obj-SCD individuals.
To compare Obj-SCD brain function changes with those in mild cognitive impairment (MCI).
To investigate the correlation between brain activity and cognitive performance in Obj-SCD.

Main Methods:

Included 37 healthy controls (HC), 25 Obj-SCD, and 28 amnestic MCI (aMCI) participants.
Utilized resting-state functional magnetic resonance imaging (fMRI) and neuropsychological tests.
Analyzed fractional amplitude of low-frequency fluctuations (fALFF) to assess local brain activity.

Main Results:

Obj-SCD and aMCI groups showed similar functional enhancements in the left inferior frontal gyrus and left cingulate gyrus.
Obj-SCD exhibited distinct patterns: increased activity in the right middle occipital gyrus, decreased in left precuneus and left inferior temporal gyrus compared to HC.
fALFF values in Obj-SCD correlated uniquely with cognitive scores (MMSE, AFT), differing from aMCI correlations.

Conclusions:

Obj-SCD presents a unique brain functional activity pattern.
These functional changes correlate distinctly with cognitive performance, suggesting a complex pathology.
Obj-SCD may represent a distinct preclinical stage preceding aMCI, aiding in the study of cognitive decline.