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COVID-19 Recurrence Without Seroconversion in a Patient With Mannose-Binding Lectin Deficiency
Breanne Hayes1, Jonathan Stanley2, Brian P Peppers3
1Internal Medicine Residency Program, West Virginia University Medicine, Morgantown, West Virginia.
Individuals with mannose binding lectin deficiency may face a higher risk of SARS-CoV-2 reinfection. This case highlights a patient with MBL deficiency who experienced two COVID-19 infections without developing lasting antibodies.
Area of Science:
- Immunology
- Infectious Diseases
- Virology
Background:
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in December 2019, leading to a global pandemic.
- Reinfection with SARS-CoV-2, though uncommon, has been documented in numerous cases.
- Mannose-binding lectin (MBL) plays a crucial role in the innate immune system's defense against pathogens.
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