Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...

Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Three-dimensional nanophotonics with spatially modulated optical properties.

Light, science & applications·2026

Same author

Quantized Crystalline-Electromagnetic Responses in Insulators.

Physical review letters·2026

Same author

Non-reciprocal frequency conversion in a non-Hermitian multimode nonlinear system.

Nature communications·2025

Same author

Large-scale self-assembled nanophotonic scintillators for X-ray imaging.

Nature communications·2025

Same author

Pattern of lumbar disc degeneration in young adults with low back pain on 3T magnetic resonance imaging machine.

JPMA. The Journal of the Pakistan Medical Association·2025

Same author

End-to-end design of multicolor scintillators for enhanced energy resolution in X-ray imaging.

Light, science & applications·2025

Search research articles

Related Experiment Video

Updated: Nov 1, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Pirfenidone-Induced Photosensitive Dermatitis: A Rare Side Effect.

Ramsha Saleem¹, Sachin Vaidya²

¹Medicine, Royal Adel, Adelaide, AUS.

|June 28, 2021

Summary

Pirfenidone, an anti-inflammatory drug for idiopathic pulmonary fibrosis (IPF), can cause photosensitive reactions. A patient developed a rash from pirfenidone, which cleared after stopping the medication.

Keywords:

anti-inflammatory drugs cutaneous immunology drug eruption photosensitive rash pirfenidone

More Related Videos

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

Related Experiment Videos

Last Updated: Nov 1, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

Area of Science:

Pharmacology
Dermatology
Pulmonology

Background:

Pirfenidone is a medication used to treat idiopathic pulmonary fibrosis (IPF).
Drug-induced photosensitivity is a known adverse effect of various medications.
Anti-inflammatory drugs, including pirfenidone, are among those that can cause photosensitivity.

Observation:

A patient undergoing treatment for IPF with pirfenidone developed a photosensitive rash.
The rash appeared as a reaction to the prescribed pirfenidone medication.

Findings:

Discontinuation of pirfenidone led to the resolution of the photosensitive rash.
This case highlights pirfenidone as a potential cause of drug-induced photosensitivity.

Implications:

Clinicians should be aware of the risk of photosensitivity in patients taking pirfenidone.
Monitoring for and managing photosensitive reactions is crucial for IPF patients on pirfenidone.
This finding contributes to the understanding of pirfenidone's adverse effect profile.