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Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value

Yukun Li1, Juan Zou1, Qunfeng Zhang1

  • 1Department of Obstetrics and Gynecology, The Second Affiliated Hospital of University of South China, Hengyang, China.

Frontiers in Oncology
|June 28, 2021
PubMed

Insights

The Microliposome maintenance (MCM) complex, a DNA replication regulator, is elevated in ovarian cancer. This MCM complex shows potential as a prognostic marker and therapeutic target for ovarian cancer patients.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Microliposome maintenance (MCM) 2-7 proteins regulate DNA replication and are implicated in various cancers.
  • The specific role of the MCM complex in ovarian cancer (OC) progression remains largely uncharacterized.

Purpose of the Study:

  • To elucidate the biological functions of the MCM complex in ovarian cancer.
  • To determine the prognostic significance of the MCM complex in ovarian cancer patients.

Main Methods:

  • Analysis of DNA alterations, mRNA, and protein expression using databases like TCGA and CPTAC.
  • Investigation of protein structure, protein-protein interaction (PPI) networks, and functional enrichment.
  • Prognostic value assessment using survival analysis and GSCALite.

Main Results:

  • Significantly elevated protein levels of MCM complex members were observed in ovarian cancer.
  • A prognostic signature derived from the MCM complex demonstrated moderate predictive performance for overall survival (OS) in OC.
  • Functional analyses indicated the MCM complex promotes OC progression by enhancing DNA replication and cell cycle.

Conclusions:

  • The MCM complex plays a synergistic role in promoting ovarian cancer progression.
  • The MCM complex represents a potential therapeutic target and prognostic biomarker for ovarian cancer.
Keywords:
The minichromosome maintenance (MCM) complexcomprehensive bioinformaticsovarian cancerprognostic valuepublic databases

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