Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Skeletal Muscle Fibers01:32

Types of Skeletal Muscle Fibers

3.4K
Skeletal muscles comprise various fibers, each with distinct characteristics and roles in movement and stability. They are mainly categorized into three types — fast-twitch, slow-twitch, and intermediate.
Fast-twitch fibers
Fast-twitch fibers, or Type II fibers, are designed for quick, powerful bursts of speed and strength. They reach peak tension within approximately 0.01 seconds following stimulation. Characterized by a large diameter and densely packed myofibrils, these fibers contain...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility of strong diffusion encoding and fast readout using a plug-and-play head gradient insert at 7 T.

Magnetic resonance in medicine·2025
Same author

Rapid differentiation of MOGAD and MS after a single optic neuritis.

Journal of neurology·2024
Same author

Generation of two induced pluripotent stem cell lines (HIMRi006-A and HIMRi007-A) from Pompe patients with infantile and late disease onset.

Stem cell research·2024
Same author

Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C.

Stem cell research·2024
Same author

Monitoring Nusinersen Treatment Effects in Children with Spinal Muscular Atrophy with Quantitative Muscle MRI.

Journal of neuromuscular diseases·2023
Same author

Generation of two human iPSC lines (HIMRi002-A and HIMRi003-A) derived from Caveolinopathy patients with rippling muscle disease.

Stem cell research·2023
Same journal

Disease progression and economic burden of duchenne muscular dystrophy: A retrospective study using Swedish register data.

Journal of neuromuscular diseases·2026
Same journal

Functional disease progression in children with inherited peripheral neuropathies: A prospective cohort study.

Journal of neuromuscular diseases·2026
Same journal

Facilitators and barriers to exercise in autoimmune myasthenia gravis: A cross-sectional survey study.

Journal of neuromuscular diseases·2026
Same journal

Analysis of diagnostic pitfalls in 125 genetically confirmed cases of distal myopathies.

Journal of neuromuscular diseases·2026
Same journal

Meeting report: 2025 muscular dystrophy association summit on 'safety and challenges in gene therapy of neuromuscular diseases'.

Journal of neuromuscular diseases·2026
Same journal

Time-efficient coronal MRI reflects clinical and pathological features of myopathies.

Journal of neuromuscular diseases·2026
See all related articles

Related Experiment Video

Updated: Oct 31, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.7K

Diffusion Tensor Imaging Shows Differences Between Myotonic Dystrophy Type 1 and Type 2.

R Rehmann1, C Schneider-Gold2, M Froeling3

  • 1Department of Neurology, Heimer Institute for Muscle Research, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.

Journal of Neuromuscular Diseases
|June 28, 2021
PubMed
Summary
This summary is machine-generated.

Muscle diffusion tensor imaging (mDTI) and fat-quantification can differentiate between Myotonic Dystrophy type 1 and type 2. These MRI techniques reveal distinct muscle involvement patterns, aiding in diagnosis and follow-up.

Keywords:
Myotonic Dystrophy type 1Myotonic Dystrophy type 2diffusion tensor imagingmagnetic resonance imagingmuscleskeletal

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.7K
An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery
08:08

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

Published on: May 11, 2011

14.1K

Related Experiment Videos

Last Updated: Oct 31, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.7K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.7K
An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery
08:08

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

Published on: May 11, 2011

14.1K

Area of Science:

  • Biomedical Imaging
  • Neuromuscular Disorders
  • Quantitative MRI

Background:

  • Myotonic Dystrophies (DM) type 1 and type 2 are inherited myopathies causing progressive muscle degeneration.
  • Distinct muscle diffusion patterns between DM1 and DM2 have not been previously established.

Purpose of the Study:

  • To assess the utility of muscle diffusion tensor imaging (mDTI) and Dixon fat-quantification in differentiating DM1 from DM2.
  • To identify unique muscle involvement patterns associated with each DM type.

Main Methods:

  • 10 DM1 patients, 13 DM2 patients, and 28 healthy controls (HC) underwent MRI of thigh and calf muscles.
  • Quantitative mDTI parameters (λ1, MD, RD, FA) and fat-fraction were analyzed.
  • Correlation between CTG-triplet repeat length (DM1) and MRI metrics was investigated.

Main Results:

  • mDTI demonstrated significant diffusion parameter differences in thigh muscles between DM1/DM2 and HC (p < 0.001), except for FA.
  • Calf muscles showed significant mDTI differences between DM1 and DM2 patients (p < 0.0001) and between DM1 and HC (p = 0.0001).
  • Both DM groups exhibited increased thigh muscle fat-fraction compared to HC (p < 0.05).

Conclusions:

  • mDTI and fat-quantification reveal specific muscle diffusion and fat changes in DM1 and DM2.
  • These quantitative MRI methods offer a valuable tool for the differential diagnosis and monitoring of DM1 and DM2.
  • Further validation in larger cohorts is recommended.