Related Experiment Video
Updated: Oct 31, 2025

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model
Published on: March 28, 2025
[Paramecium, a model organism to study ciliogenesis and ciliopathies]
Khaled Bouhouche1, Pierrick Le Borgne1, Michel Lemullois1
1Université Paris-Saclay, CEA, CNRS, Institut de biologie intégrative de la cellule (I2BC), 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Abstract:
The cilium is a cell extension forming a distinct compartment of eukaryotic cell body with a complex and dynamic structure. This structure is highly conserved across species and ensures various functions as sensory and motility. In humans, ciliary dysfunction results in diseases (ciliopathies) that can affect all organs. Thanks to its complex ciliary structure, the unicellular and ciliated microorganism, Paramecium, constitutes a model of choice not only to study the structure, assembly and function of cilia but also to validate the specific role of mutations of genes linked to the ciliopathies.
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