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TP53 codon 72 polymorphism and type 2 diabetes: a case-control study in South Indian population

Harshitha K Punja1, Dechamma Pandyanda Nanjappa2, Nishith Babu2

  • 1Department of General Medicine, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangaluru, 575018, India.

Molecular Biology Reports
|June 28, 2021
PubMed

Insights

The TP53 tumor suppressor gene plays a role in cell health. This study found no link between the TP53 codon 72 polymorphism and type 2 diabetes risk in South Indians.

Area of Science:

  • Genetics
  • Molecular Biology
  • Endocrinology

Background:

  • The TP53 gene is a crucial tumor suppressor involved in various cellular processes, including metabolism.
  • Evidence suggests TP53's involvement in diabetes, but genetic associations remain inconsistent.
  • The TP53 codon 72 Pro72/Arg72 polymorphism is one such variant investigated for its role in disease.

Purpose of the Study:

  • To investigate the association between the TP53 codon 72 (Pro72/Arg72) polymorphism and type 2 diabetes (T2D) risk.
  • To analyze the prevalence of TP53 genotypes in a South Indian population with and without T2D.
  • To contribute to understanding the genetic underpinnings of T2D in diverse ethnic groups.

Main Methods:

  • Genotyping of the TP53 codon 72 C/G polymorphism (Pro72/Arg72) using DNA from 74 T2D patients and 54 non-diabetic controls.
  • Analysis of genotype frequencies (C/C, C/G, G/G) between the case and control groups.
  • Statistical evaluation to determine significant associations between genotypes and T2D risk.

Main Results:

  • No significant association was found between any of the TP53 codon 72 genotypes (Pro/Pro, Pro/Arg, Arg/Arg) and type 2 diabetes.
  • The distribution of C/C, C/G, and G/G genotypes did not differ significantly between diabetic patients and controls.
  • This study is the first to examine TP53 variants in relation to T2D in the South Indian population.

Conclusions:

  • The TP53 codon 72 polymorphism is not associated with an increased risk of type 2 diabetes in the studied South Indian population.
  • Further research with larger cohorts is needed to confirm these findings.
  • Genetic variations in TP53 may not be a significant risk factor for T2D in this specific demographic.
Keywords:
Genetic alterationsIndian cohortInsulin resistanceMetabolic disorderTumor protein p53

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