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Updated: Sep 15, 2025

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

Biomedical Models: Use of Zebrafish as a Multi-Utility In Vivo Tool Box.

Barsha Mohanty¹, Masmarika Mohan¹, Dechamma Pandyanda Nanjappa¹

¹Department of Molecular Genetics and Cancer, NITTE (Deemed to Be University), Nitte University Centre for Science Education and Research (NUCSER), Mangaluru, Karnataka, India.

Wires Mechanisms of Disease

|July 18, 2025

Summary

This summary is machine-generated.

Zebrafish offer unique advantages for biomedical research, serving as a versatile genetic tool. Their genetic similarity to humans and advanced manipulation techniques enable breakthroughs in disease modeling and drug discovery.

Keywords:

OMICS cancer research genetic disorders genome editing infectious disease

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Last Updated: Sep 15, 2025

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Published on: June 19, 2021

Area of Science:

Biomedical Research
Genetics
Genomics
Molecular Biology

Background:

Molecular research has evolved, shifting from unidirectional studies to integrated OMICs approaches.
Multi-omics data (genomic, transcriptomic, proteomic, metabolomic) are crucial for understanding disease pathophysiology.
Zebrafish present numerous advantages as a vertebrate model in biomedical research.

Purpose of the Study:

To review advances in zebrafish-based biomedical research.
To highlight zebrafish applications in disease modeling, functional omics, toxicology, and pharmacology.
To underscore the utility of zebrafish as a genetic research tool.

Main Methods:

Review of current scientific literature on zebrafish research.
Analysis of zebrafish genetic conservation and manipulation techniques.
Integration of multi-omics data in zebrafish models.

Main Results:

Zebrafish exhibit high genetic conservation with humans.
Advanced gene manipulation techniques are readily available for zebrafish.
Zebrafish are effectively utilized in disease modeling, omics studies, toxicology, and pharmacology.

Conclusions:

Zebrafish are a powerful and versatile tool for biomedical research.
The integration of multi-omics data in zebrafish models enhances disease understanding.
Zebrafish research significantly contributes to genetics, genomics, and molecular physiology studies.