Biomedical Models: Use of Zebrafish as a Multi-Utility In Vivo Tool Box

Area of Science:

• Biomedical Research
• Genetics
• Genomics
• Molecular Biology

Background:

• Molecular research has evolved, shifting from unidirectional studies to integrated OMICs approaches.
• Multi-omics data (genomic, transcriptomic, proteomic, metabolomic) are crucial for understanding disease pathophysiology.
• Zebrafish present numerous advantages as a vertebrate model in biomedical research.

Purpose of the Study:

• To review advances in zebrafish-based biomedical research.
• To highlight zebrafish applications in disease modeling, functional omics, toxicology, and pharmacology.
• To underscore the utility of zebrafish as a genetic research tool.

Main Methods:

• Review of current scientific literature on zebrafish research.
• Analysis of zebrafish genetic conservation and manipulation techniques.
• Integration of multi-omics data in zebrafish models.

Main Results:

• Zebrafish exhibit high genetic conservation with humans.
• Advanced gene manipulation techniques are readily available for zebrafish.
• Zebrafish are effectively utilized in disease modeling, omics studies, toxicology, and pharmacology.

Conclusions:

• Zebrafish are a powerful and versatile tool for biomedical research.
• The integration of multi-omics data in zebrafish models enhances disease understanding.
• Zebrafish research significantly contributes to genetics, genomics, and molecular physiology studies.