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Updated: Oct 31, 2025

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
Published on: August 15, 2025
Phosphorylation of polysaccharides: A review on the synthesis and bioactivities
Shunli Xia1, Yongcong Zhai1, Xue Wang1
1School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, PR China.
Abstract:
Polysaccharides are macromolecules obtained from a wide range of sources and are known to have diverse biological activities. The biological activities of polysaccharides depend on their structure and physicochemical properties, including water solubility, monosaccharide composition, degree of branching, molecular structure, and molecular weight. Phosphorylation is a commonly used chemical modification method that improves the physicochemical properties of native polysaccharides, thus enhancing their biological activity, or even imparting novel biological activity. Therefore, phosphorylated polysaccharides have attracted increasing attention owing to their antioxidant, antitumor, antiviral, immunomodulatory, and hepatoprotective effects. In this review, we have discussed recent advances in the phosphorylation of polysaccharides, and the methods used for phosphorylation, structural characterization, and determination of biological activities, to provide a theoretical basis for the use of polysaccharides. The structure-activity relationship of phosphorylated polysaccharides and their use in the food and pharmaceutical industries needs to be further studied.
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