Chemodynamic nanomaterials for cancer theranostics

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Cancer mortality necessitates advanced therapeutic strategies.
• Fenton-reaction-based chemodynamic therapy (CDT) offers a novel approach to enhance anticancer efficacy.
• CDT utilizes the generation of reactive oxygen species (ROS) and oxygen (O2) for antitumor effects.

Purpose of the Study:

• To review the antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials in chemodynamic therapy.
• To highlight the dual role of CDT in direct cancer cell killing and combination therapy enhancement.
• To discuss the potential of CDT-based nanomaterials in cancer therapy, including diagnosis and monitoring.

Main Methods:

• Review of literature on Fenton-reaction-based nanomaterials for cancer therapy.
• Analysis of mechanisms for ROS and O2 generation in the tumor microenvironment (TME).
• Exploration of synergistic effects of CDT with other therapeutic modalities.

Main Results:

• Fenton-based CDT nanomaterials generate ROS in-situ for direct cancer cell apoptosis.
• CDT-mediated oxygen production alleviates tumor hypoxia, enhancing other therapies like photodynamic therapy and radiotherapy.
• CDT strategies show potential for integrated cancer diagnosis, monitoring, and therapy.

Conclusions:

• Fenton-reaction-based CDT nanomaterials represent a promising strategy for effective cancer treatment.
• The ability of CDT to produce ROS and O2 offers versatile therapeutic applications.
• CDT-based nanomaterials hold significant potential for synergistic combination therapies and theranostics in oncology.