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The One-Step Incorporation of Boron-10 Atom into Prostate Cancer-Targeted Fluorophores for Visualizing In Vivo
Jingqi Xin1,2, Jingjing Zhang1, Feifei An1
1School of Public Health, Health Science Center, Xi'an Jiaotong University, No.76 Yanta West Road, Xi'an 710061, Shaanxi, China.
None:
To enable real-time imaging of boron delivery with cellular resolution, a series of fluorescent [10B] compounds was developed via a one-step synthesis using cost-effective, scalable reagents. The tumor-targeting agent, [10B]-a11, allowed noninvasive monitoring to identify the optimal time point for boron neutron capture therapy (BNCT) based on peak tumor accumulation. Fluorescence imaging analysis revealed a heterogeneous intratumoral distribution of [10B]-a11, confirming that macroscopic accumulation does not equate to microscopic uniformity and emphasizing the need for improved tumor penetration in next-generation boron carriers. Furthermore, [10B]-a11 demonstrated efficacy for fluorescence-guided surgery in prostate cancer, suggesting a potential synergistic strategy to combine precise resection with BNCT for improved therapeutic outcomes.
