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Updated: Oct 31, 2025
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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
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Novel treatments in multidrug-resistant tuberculosis
Michele Mondoni1, Laura Saderi2, Giovanni Sotgiu2
1Respiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
Current Opinion in Pharmacology
|June 29, 2021
Summary
New drugs like bedaquiline and delamanid offer hope for treating drug-resistant tuberculosis (TB), improving outcomes. Advances in drug delivery and supportive care also enhance treatment strategies for resistant TB.
Area of Science:
- Infectious Diseases
- Pulmonology
- Pharmacology
Background:
- Multidrug-resistant tuberculosis (TB) presents significant challenges with high mortality and low treatment success rates.
- Recent advancements in novel drugs and short-therapeutic regimens are crucial for overcoming these obstacles.
Purpose of the Study:
- To summarize scientific evidence on recent therapeutic advances in drug-resistant TB management.
- To describe novel drugs, regimens, and their pharmacological characteristics.
- To highlight complementary therapeutic strategies beyond standard chemotherapy.
Main Methods:
- Narrative literature review.
- Inclusion of experimental and observational studies.
- Focus on novel drugs (bedaquiline, delamanid, pretomanid) and regimens.
Main Results:
- Novel drugs like bedaquiline, delamanid, and pretomanid show promise in treating drug-resistant TB.
- New short-therapeutic regimens are emerging as effective treatment options.
- Complementary strategies including advanced drug delivery, host-directed therapy, surgery, and palliative care are discussed.
Conclusions:
- Recent therapeutic advances offer improved options for managing drug-resistant TB.
- Novel drugs and regimens, alongside complementary strategies, are vital for enhancing treatment success and reducing mortality.
- Further research into these advancements is essential for combating TB.
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