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Updated: Oct 31, 2025

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Bidirectional relationship between subjective age and frailty: a prospective cohort study
Yuxiao Li1, Minhui Liu2,3, Christina E Miyawaki4
1Xiangya School of Nursing, Central South University, 172 Tongzipo Road of Yuelu District, Hunan, 410013, Changsha, China.
Older adults who feel older than their chronological age are more likely to experience frailty. Subjective age can serve as an economical screening tool for frailty risk in older populations.
Area of Science:
- Gerontology
- Public Health
- Biomedical Science
Background:
- Subjective age, or how old one feels, is linked to various health indicators.
- Frailty is a significant concern in older adults, impacting health and independence.
- The relationship between subjective age and frailty requires further investigation.
Purpose of the Study:
- To examine the bidirectional association between subjective age and frailty.
- To investigate this relationship in community-dwelling older adults.
Main Methods:
- Utilized data from the National Health and Aging Trends Study (2011-2015).
- Included 2,592 community-dwelling older adults.
- Measured subjective age via self-report and frailty using five phenotypic criteria (exhaustion, weight loss, low physical activity, slow gait, weak grip strength).
- Employed generalized estimating equation models to analyze concurrent and lagged associations.
Main Results:
- The average participant age was 75.2 years; 76% were non-Hispanic white and 58% were female.
- 77% of participants felt younger than their chronological age.
- An older subjective age was associated with a higher likelihood of pre-frailty and frailty (OR=1.93, 95% CI=1.45-2.56).
Conclusions:
- Older subjective age is a predictor of increased pre-frailty and frailty.
- Subjective age can be a valuable, cost-effective tool for screening individuals at risk of frailty.
- This highlights the importance of perceived age in geriatric health assessments.
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