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Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis

Lei Shi1, Kexin Wang1, Jinghong Yu1

  • 1Radiology Department, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010020 Inner Mongolia China.

Indian Journal of Orthopaedics
|June 30, 2021
PubMed
Abstract

Insights

Quantitative MRI T2-mapping shows increased T2 values correlating with cartilage degeneration in knee osteoarthritis (KOA). This T2 value increase is linked to higher matrix metalloproteinase (MMP-1, MMP-3) expression, suggesting their role in KOA pathogenesis.

Area of Science:

  • Biomedical imaging and osteoarthritis research.
  • Biochemistry and molecular biology of cartilage degradation.

Background:

  • Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage breakdown.
  • Matrix metalloproteinases (MMPs), particularly MMP-1 and MMP-3, are implicated in OA pathogenesis.
  • Quantitative magnetic resonance imaging (MRI) techniques like T2-mapping offer potential for assessing cartilage integrity.

Purpose of the Study:

  • To explore the relationship between quantitative MRI T2-mapping values and MMP-1, MMP-3 expression in knee osteoarthritis (KOA).
  • To elucidate the role of MMP-1 and MMP-3 in the pathological processes of KOA.

Main Methods:

  • Thirty KOA patients undergoing total knee arthroplasty (TKA) and 30 healthy controls underwent 1.5 T MRI with T2-mapping.
  • T2 values of knee cartilage were measured and statistically analyzed.
  • Expression levels of MMP-1 and MMP-3 in surgically removed cartilage were quantified using immunohistochemical assays.

Main Results:

  • T2 values significantly increased with the severity of cartilage degeneration according to both MRI Recht grading and Mankin pathological grading (P < 0.05).
  • Expression of MMP-1 and MMP-3 was found to increase concurrently with cartilage degeneration.
  • A significant positive linear correlation was observed between cartilage T2 values and the expression levels of MMP-1 and MMP-3.

Conclusions:

  • Quantitative MRI T2-mapping effectively reflects the degree of cartilage degeneration in KOA.
  • Elevated MMP-1 and MMP-3 expression correlates with advanced cartilage destruction in KOA.
  • T2 values derived from MRI show a positive association with MMP-1, MMP-3 expression, highlighting their potential as biomarkers in KOA.
Keywords:
Articular cartilageMMP-1,3T2-mapping

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