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Updated: Oct 31, 2025

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Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers

Ammad Ahmad Farooqi1, Kapanova Gulnara2, Auyezova Ardak Mukhanbetzhanovna3

  • 1Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.

Non-Coding RNA Research
|June 30, 2021
PubMed

Insights

RUNX proteins act as a double-edge sword in cancer. This review details the intricate interplay between non-coding RNAs and RUNX proteins, offering insights for cancer therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • RUNX proteins exhibit dual roles in cancer progression.
  • Non-coding RNAs are crucial regulators of gene expression.
  • Emerging research highlights RUNX proteins and non-coding RNA interactions.

Purpose of the Study:

  • To review the complex relationship between non-coding RNAs and RUNX proteins in various cancers.
  • To elucidate the mechanisms of cross-regulation between these molecules.
  • To bridge the gap between laboratory findings and clinical applications.

Main Methods:

  • Literature review of recent research on non-coding RNAs and RUNX proteins.
  • Analysis of mechanistic insights into their regulatory interactions.
  • Synthesis of current understanding of their roles in different cancer types.

Main Results:

  • Non-coding RNAs modulate RUNX protein activity and expression.
  • RUNX proteins influence the expression and function of non-coding RNAs.
  • This interplay is critical in diverse cancer signaling pathways.

Conclusions:

  • Understanding the layered regulation of RUNX proteins by non-coding RNAs is vital.
  • This knowledge can facilitate the development of novel cancer therapies.
  • Targeting non-coding RNA-RUNX interactions holds therapeutic potential.
Keywords:
ApoptosisCancerNon-coding RNAsSignalingTherapy

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