Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

178
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
178
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

105
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
105
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

289
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
289
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

331
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
331
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

101
IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
101
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

284
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charge Diffusion and Repulsion in Semiconductor Detectors.

Sensors (Basel, Switzerland)·2024
Same author

Active and passive dosimetry for beta-emitting radiopharmaceutical therapy agents in a custom SPECT/CT compatible phantom.

Physics in medicine and biology·2024
Same author

Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with <sup>18</sup>F-fluoroestradiol (<sup>18</sup>F-FES) CT/PET.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Identifying Defects without <i>a priori</i> Knowledge in a Room-Temperature Semiconductor Detector Using Physics Inspired Machine Learning Model.

Sensors (Basel, Switzerland)·2024
Same author

Exploring the Limitations of Hybrid Adiabatic Quantum Computing for Emission Tomography Reconstruction.

Journal of imaging·2023
Same author

Method for comparison of data driven gating algorithms in emission tomography.

Physics in medicine and biology·2023
Same journal

Exploring the applicability of a lesion segmentation method on [<sup>18</sup>F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma.

European journal of hybrid imaging·2023
Same journal

Head-to-head comparison of <sup>18</sup>F-FDG and <sup>18</sup>F-FES PET/CT for initial staging of ER-positive breast cancer patients.

European journal of hybrid imaging·2023
Same journal

Comparative analysis of two timepoints on [<sup>18</sup>F]FAPI-42 PET/CT in various cancers.

European journal of hybrid imaging·2023
Same journal

Added value of regional <sup>18</sup>F-FDG PET/MRI-assisted whole-body <sup>18</sup>F-FDG PET/CT in malignant ascites with unknown primary origin.

European journal of hybrid imaging·2023
Same journal

Signet cell rectal carcinoma with prostatic involvement detected by FAPI-04 PET-MRI fusion.

European journal of hybrid imaging·2023
Same journal

[<sup>18</sup>F]PSMA-1007 PET is comparable to [<sup>99m</sup>Tc]Tc-DMSA SPECT for renal cortical imaging.

European journal of hybrid imaging·2023
See all related articles

Related Experiment Video

Updated: Oct 31, 2025

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.5K

ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging.

A H Vija1, P A Bartenstein2, J W Froelich3

  • 1Molecular Imaging, Siemens Medical Solutions USA, Inc, Hoffman Estates, IL, USA. hans.vija@siemens-healthineers.com.

European Journal of Hybrid Imaging
|June 30, 2021
PubMed
Summary
This summary is machine-generated.

A new SPECT/CT reconstruction platform improves bone imaging resolution and lesion detection. This quantitative approach enhances reader confidence and accuracy in identifying cancerous bone lesions, aiding clinical decision-making.

Keywords:
AUCBone imagingConcordanceDPDDiphosphonateMDPQuantitative SPECTROCSPECT/CTSUVTc99mxSPECT bonexSPECT quant

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

938

Related Experiment Videos

Last Updated: Oct 31, 2025

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.5K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

938

Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Investigated clinical performance of quantitative multi-modal SPECT/CT reconstruction for bone imaging using 99mTc-MDP or 99mTc-DPD.
  • Novel reconstruction incorporates CT-derived tissue information while preserving tissue boundary delineation.
  • Assessed image-based reader concordance, confidence, lesion classification, and SUV thresholds via ROC analysis.

Purpose of the Study:

  • To evaluate a quantitative multi-modal SPECT/CT reconstruction platform for bone imaging.
  • To assess the impact of CT-derived tissue information on image quality, reader performance, and lesion characterization.
  • To determine SUV thresholds for differentiating benign and malignant bone lesions.

Main Methods:

  • Compared four reconstruction variants (Flash3D and xSPECT Bone™ with and without CT fusion) using data from 72 cancer patients across five clinical sites.
  • Nine experienced nuclear medicine physicians served as readers, performing all-or-none reads.
  • Utilized surrogate truth and consensus reads for discordant lesions, followed by ROC analysis to determine SUV thresholds.

Main Results:

  • xSPECT Bone™ (xB) demonstrated superior resolution and overall acceptance compared to Flash3D (F3D).
  • Reader agreement and confidence in lesion characterization were significantly higher with CT information, particularly with xBCT.
  • xB showed improved sensitivity, specificity, and AUC for lesion detection compared to F3D, with greater impact on smaller lesions.

Conclusions:

  • High-resolution CT-based tissue delineation in SPECT reconstruction (xSPECT Bone) enhances resolution and detects smaller lesions.
  • The CT component facilitates lesion characterization, increasing reader confidence, concordance, and accuracy.
  • Quantitative assessment provides SUV thresholds for distinguishing benign and malignant lesions, with ongoing efforts to establish clinical protocols.