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Updated: Oct 31, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

845

Retraction

    Journal of Cellular Biochemistry
    |June 30, 2021
    PubMed

    Insights

    This study on non-small cell lung cancer is retracted due to duplicated image data. The findings regarding microRNA-145-3p, PDK1, and mTOR signaling are now considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biochemistry

    Context:

    • Investigated the role of microRNA-145-3p in non-small cell lung cancer (NSCLC).
    • Focused on the potential inhibitory effects of microRNA-145-3p on cancer cell migration and invasion.
    • Explored the involvement of PDK1 and the mTOR signaling pathway in NSCLC progression.

    Purpose:

    • To determine if microRNA-145-3p could inhibit non-small cell lung cancer cell migration and invasion.
    • To elucidate the mechanism by which microRNA-145-3p exerts its effects, specifically by targeting PDK1.
    • To examine the influence of this interaction on the mammalian target of rapamycin (mTOR) signaling pathway.

    Summary:

    • The study suggested that microRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion.
    • This inhibition was proposed to occur through the targeting of PDK1, a key regulator in cellular metabolism and signaling.
    • The mechanism was linked to the modulation of the mTOR signaling pathway, crucial for cell growth and proliferation.

    Impact:

    • The article has been retracted due to significant image duplication issues in the experimental data.
    • The editors have invalidated the conclusions, meaning the proposed role of microRNA-145-3p in NSCLC is not supported.
    • This retraction highlights the importance of data integrity and verification in scientific publishing.

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