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Updated: Oct 31, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

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Retraction

    Journal of Cellular Biochemistry
    |June 30, 2021
    PubMed

    Insights

    This study on colorectal cancer cells is retracted due to data duplication. The original research investigated pyruvate kinase M2 (PKM2) gene silencing effects on cancer cell behaviors.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biochemistry

    Context:

    • The study investigated the role of pyruvate kinase M2 (PKM2) in colorectal cancer.
    • PKM2 is implicated in regulating cellular metabolism and cancer progression.

    Purpose:

    • To examine the effects of shRNA-mediated silencing of the PKM2 gene on aerobic glycolysis, cell migration, cell invasion, and apoptosis in colorectal cancer cells.

    Summary:

    • The article "Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells" has been retracted.
    • The retraction was based on findings of duplicated image elements in the experimental data, compromising the study's conclusions.
    • The journal editors invalidated the article's findings due to the data integrity issues.

    Impact:

    • This retraction highlights the importance of rigorous data verification in scientific publishing.
    • It underscores the need for maintaining high standards of research integrity in cancer studies.
    • The invalidation of conclusions necessitates re-evaluation of PKM2's role in colorectal cancer based on reliable data.

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