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Updated: Oct 31, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Embedding a COVID-19 group sequential clinical trial within an ongoing trial: lessons from an unusual experience
Pierre-François Dequin1, Amélie Le Gouge2, Elsa Tavernier2
1Service de Médecine Intensive-Réanimation, CHRU de Tours, France; INSERM U1100, Centre d'Etude des Pathologies Respiratoires, Université de Tours, Tours, France.
Abstract:
The Cape-Covid trial is an embedded clinical trial within the ongoing Cape-Cod trial. The Covid-19 pandemic appeared while we were conducting a randomized trial assessing the effectiveness of corticosteroids in severe community-acquired pneumonia. We took advantage of this ongoing trial to embed a sub-trial assessing hydrocortisone in SARS-CoV-2 infected patients. In this manuscript, we wish to share our experience when we needed to make fast and robust methodological decisions during the Covid-19 pandemic in a two weeks period of time.
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