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Updated: Oct 31, 2025
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Acute localized exanthematous pustulosis caused by enoxaparin
N Mozafari1,2, M Farjami3, E Jamali4
1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical and Experimental Dermatology
|June 30, 2021
Summary
Enoxaparin, a common anticoagulant, has been identified as a potential cause of acute localized exanthematous pustulosis (ALEP), a rare skin reaction. This finding expands the known spectrum of drug-induced dermatoses associated with this medication.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Enoxaparin is a widely used low-molecular-weight heparin anticoagulant.
- Acute localized exanthematous pustulosis (ALEP) is a rare, specific type of cutaneous drug eruption characterized by sterile pustules.
Observation:
- A case report details a patient who developed a drug reaction consistent with ALEP.
- The reaction occurred following administration of enoxaparin.
Findings:
- This case is the first to describe enoxaparin as a causative agent for acute localized exanthematous pustulosis.
- The findings suggest enoxaparin can induce ALEP.
Implications:
- This report expands the differential diagnosis for drug-induced pustular eruptions.
- Clinicians should consider enoxaparin when evaluating patients with ALEP, especially those on anticoagulant therapy.
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