Related Experiment Video
Updated: Jul 27, 2026

10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
25.9K
Large Brunner's Gland Hyperplasia with Bleeding: A Case Report.
Yuki Okutomi1, Takaharu Kato1, Hidetoshi Aizawa1
1Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.
Case Reports in Surgery
|July 1, 2021
Summary
A rare case of large Brunner's gland hyperplasia (BGH) caused severe anemia in a 33-year-old woman. Surgical resection of the duodenal tumor successfully treated the condition, highlighting BGH's potential for serious complications.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Brunner's gland hyperplasia (BGH) is a rare duodenal condition.
- While often asymptomatic, BGH can present with significant complications.
Observation:
- A 33-year-old woman presented with severe anemia (hemoglobin 4.9 g/dL) and a large duodenal mass.
- Imaging revealed a 7 cm tumor in the descending duodenum; endoscopy showed a polypoid mass with an ulcer.
- The patient experienced melena and shortness of breath, necessitating a blood transfusion.
Findings:
- Surgical resection of the 7.0 × 4.0 × 2.3 cm duodenal tumor was performed.
- Pathological examination confirmed Brunner's gland hyperplasia with no evidence of malignancy.
- The tumor was located at the duodenal bulb, with the ampulla uninvolved.
Implications:
- This case underscores that large BGH can lead to severe anemia and bleeding.
- Awareness of potential complications like anemia and obstruction is crucial for managing BGH.
- Surgical intervention is effective for symptomatic BGH, preventing further gastrointestinal bleeding.

