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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Abnormal Fibrinogen Level as a Prognostic Indicator in Coronavirus Disease Patients: A Retrospective Cohort Study

Wei Long1, Jie Yang2, Zhengwei Li3

  • 1Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Frontiers in Medicine
|July 1, 2021
PubMed

Insights

Abnormal fibrinogen (FIB) levels in COVID-19 patients are linked to increased mortality risk and critical disease development. Monitoring FIB may help predict patient outcomes during the pandemic.

Area of Science:

  • Medical research
  • Biomarker discovery
  • Infectious disease epidemiology

Background:

  • The COVID-19 pandemic presents a global health challenge.
  • Identifying prognostic biomarkers for COVID-19 is crucial for patient management.
  • Coagulation and fibrinolysis abnormalities are frequently observed in COVID-19 patients.

Purpose of the Study:

  • To investigate the role of fibrinogen (FIB) levels as a prognostic biomarker in COVID-19.
  • To determine the association between FIB levels and mortality risk in COVID-19 patients.
  • To assess the relationship between FIB levels and the risk of developing critical COVID-19 disease.

Main Methods:

  • Retrospective cohort study of 1,643 COVID-19 patients.
  • Patients categorized into three groups based on admission FIB levels.
  • Cox and logistic regression analyses used to determine associations with mortality and disease severity, respectively.
  • Kaplan-Meier analysis assessed survival rates across different FIB level groups.

Main Results:

  • Patients with FIB levels < 2.2 g/L and >4.2 g/L exhibited significantly higher mortality risks compared to those with normal FIB levels (2.2-4.2 g/L).
  • Kaplan-Meier survival analyses confirmed a significant association between abnormal FIB levels and reduced survival.
  • Elevated FIB levels were correlated with an increased risk of progressing to critical COVID-19 disease.

Conclusions:

  • Abnormal fibrinogen levels are associated with increased mortality risk in COVID-19 patients.
  • Fibrinogen levels can serve as a predictive marker for the development of critical COVID-19.
  • Assessing FIB levels may aid in the prognostic evaluation and clinical management of COVID-19 patients.

Keywords:
COVID-19clinical managementfibrinogenprognostic indicatorsretrospective study

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