Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hippocampal microcircuits constrain the generation of epileptiform activity.

bioRxiv : the preprint server for biology·2026

Same author

Autonomous biomedical research with an artificial intelligence agent.

Science (New York, N.Y.)·2026

Same author

Recurrent connectivity shapes spatial coding in hippocampal CA3 subregions.

Neuron·2026

Same author

Universal cell embedding provides a foundation model for cell biology.

Nature·2026

Same author

Hippocampal Long Axis Differentiation in Memory and Seizure Networks.

Epilepsy currents·2026

Same author

Bio-BLIP: A Multimodal Architecture for Transferable Reasoning in Genomic Variant Interpretation.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Oct 31, 2025

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Maximally selective single-cell target for circuit control in epilepsy models.

Darian Hadjiabadi¹, Matthew Lovett-Barron², Ivan Georgiev Raikov³

¹Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

|July 1, 2021

Summary

Researchers discovered a new brain cell type, the superhub, that drives seizures. Targeting these superhubs offers a promising new strategy for controlling epilepsy with minimal invasiveness.

Keywords:

adult-born granule cells calcium imaging effective connectivity modeling epilepsy higher-order organization hubs motifs network science seizure control single-cells

More Related Videos

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Related Experiment Videos

Last Updated: Oct 31, 2025

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Area of Science:

Neuroscience
Computational Biology
Network Science

Background:

Neurological and psychiatric disorders involve pathological neural dynamics.
The underlying cell-cell communication network patterns driving these dynamics are not fully understood.

Purpose of the Study:

To investigate the network connectivity patterns in epileptic circuits.
To identify novel cellular targets for seizure control.

Main Methods:

Utilized a computational pipeline integrating single-cell calcium imaging in zebrafish and mice.
Employed biologically constrained effective connectivity modeling and higher-order motif analysis.

Main Results:

Identified a novel cell type, the 'superhub,' emerging in the preseizure state.
Superhubs exhibit extensive feedforward connectivity, enhancing downstream excitation.
Perturbation simulations showed superhub disconnection effectively stabilizes epileptic circuits.

Conclusions:

Superhubs, particularly adult-born granule cells in the dentate gyrus, represent a key functional element in epileptic networks.
Targeting superhubs presents a novel, selective, and minimally invasive strategy for seizure control.