Related Experiment Video
Updated: Oct 31, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Early-onset colorectal cancer risk extends to second- and third-degree relatives
Heather M Ochs-Balcom1, Priyanka Kanth2, Lisa A Cannon-Albright3
1Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Introduction:
Family history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown.
Methods:
We estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database.
Results:
We observed elevated risks beyond RR = 2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively.
Discussion:
Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.
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