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Malabaricane and Isomalabaricane Triterpenoids, Including Their Glycoconjugated Forms
Valentin A Stonik1,2, Sophia A Kolesnikova1
1G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Marine Drugs
|July 2, 2021
Summary
This review covers rare malabaricane and isomalabaricane triterpenoids found in plants, fungi, and sponges. These compounds show high cytotoxicity against tumor cells and neuroprotective properties.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Medicinal Chemistry
Background:
- Malabaricane and isomalabaricane triterpenoids are rare natural products.
- These compounds are found in terrestrial plants, fungi, and marine sponges.
- Their skeletal structures are similar but differ in stereochemistry.
Purpose of the Study:
- To review the structural diversity, taxonomic distribution, biological activities, biogenesis, and synthesis of malabaricane and isomalabaricane triterpenoids.
- To highlight their evolutionary pathways and derived products.
- To discuss their significant biological activities.
Main Methods:
- Literature review of existing studies on malabaricane and isomalabaricane triterpenoids.
- Analysis of structural features and stereochemistry.
- Compilation of data on biological activities and sources.
Main Results:
- Detailed discussion of structural variations and taxonomic occurrences.
- Elucidation of biosynthetic pathways and synthetic approaches.
- Evidence of significant cytotoxicity against tumor cells and neuroprotective effects.
Conclusions:
- Malabaricane and isomalabaricane triterpenoids represent a unique class of natural products with diverse structures and origins.
- Their potent anticancer and neuroprotective activities warrant further investigation.
- Understanding their biogenesis and synthesis can lead to novel therapeutic agents.
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