Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacodynamics of Early vs Delayed Ticagrelor Loading During Cangrelor Infusion in ST-Segment Elevation Myocardial Infarction.

JACC. Cardiovascular interventions·2026

Same author

Vitamin D at hospital admission as an independent predictor of outcome of sepsis patients: Results of a secondary analysis from a "Need-Speed" trial prospective cohort.

European journal of internal medicine·2026

Same author

When the Liver Flares: Inflammatory and Immunometabolic Mechanisms Driving the Transition from MASLD to MASH.

Inflammation·2026

Same author

Higher 25(OH)D Levels at Admission Predict a Favorable Disease Evolution in Moderate-to-Severe COVID-19 Patients.

International journal of molecular sciences·2026

Same author

Continuous positive airway pressure as an alternative to deep-inspiration breath holding for mediastinal lymphoma radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

Trained Immunity in Autoimmunity: Friend, Foe, or Therapeutic Target?

Biomedicines·2026

Search research articles

Related Experiment Video

Updated: Oct 31, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Nano-Microparticle Platforms in Developing Next-Generation Vaccines.

Giuseppe Cappellano^1,2, Hugo Abreu¹, Chiara Casale¹

¹Dipartimento di Scienze della Salute, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, 28100 Novara, Italy.

|July 2, 2021

Summary

Next-generation nanoparticle vaccines, including PLGA nanoparticles, liposomes, and extracellular vesicles, offer superior CD8+ T-cell responses compared to traditional vaccines. These platforms are promising for developing innovative vaccines against viral diseases and for inverse vaccination strategies.

Keywords:

PLGA advanced vaccines extracellular vesicles liposome virus infection

More Related Videos

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Related Experiment Videos

Last Updated: Oct 31, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Area of Science:

Vaccinology
Nanotechnology
Immunology

Background:

Traditional vaccines (live-attenuated, inactivated pathogens) elicit weak CD8+ T-cell responses.
Next-generation vaccines leverage nano/microparticles for enhanced immune responses.

Purpose of the Study:

To review nanoparticle-based vaccine platforms for improved CD8+ T-cell induction.
To explore the potential of PLGA nanoparticles, liposomes, and extracellular vesicles in vaccine development.
To discuss applications in infectious disease and inverse vaccination.

Main Methods:

Review of current literature on nanoparticle vaccine technologies.
Analysis of PLGA nanoparticles, liposomes, and extracellular vesicles as vaccine carriers.
Discussion of antigen, adjuvant, and nucleic acid co-delivery strategies.

Main Results:

Nanoparticle vaccines significantly enhance CD8+ T-cell responses.
PLGA nanoparticles, liposomes, and EVs are suitable carriers for various vaccine components.
These platforms show potential for both prophylactic and therapeutic vaccination.

Conclusions:

Nanoparticle-based vaccines represent a significant advancement over traditional approaches.
PLGA-NPs, liposomes, and EVs offer versatile platforms for next-generation vaccines against viral threats and autoimmune diseases.