Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

517
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
517

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-Term Neurobehavioral Effects of Acute Respiratory Illness on Auditory-Motor Integration During Speech Production.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

The quality evaluation of information in hospice and palliative care short videos on Douyin (TikTok's Chinese version) and Bilibili: a cross-sectional study.

Frontiers in digital health·2026
Same author

Application effect of a traceability management system in the centralized reprocessing of orthopedic loaned medical instruments: A retrospective comparative study.

Medicine·2026
Same author

An Adhesive Powder Based on Sodium Carboxymethyl Cellulose and Polyacrylic Acid for Efficient Hemostasis.

ACS applied bio materials·2026
Same author

Orelabrutinib for systemic lupus erythematosus: A randomised, double-blind, placebo-controlled study.

Journal of autoimmunity·2026
Same author

Correlation Between the Portal Venous Wall Shear Stress Using Ultrasound Vector Flow Imaging and Liver Regeneration in Rats With Portal Vein Stenosis.

Ultrasound in medicine & biology·2026

Related Experiment Video

Updated: Oct 31, 2025

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications
09:08

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

12.7K

A Wirelessly Controlled Scalable 3D-Printed Microsystem for Drug Delivery.

Farzad Forouzandeh1, Nuzhet N Ahamed1, Xiaoxia Zhu2

  • 1Department of Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA.

Pharmaceuticals (Basel, Switzerland)
|July 2, 2021
PubMed
Summary

We developed a 3D-printed microsystem for precise drug delivery, featuring a wireless-controlled micropump. This implantable device showed reliable performance in mice for long-term inner ear drug delivery.

Keywords:
3D printingdrug deliveryimplantablemicropumpmicroreservoirtransdermal

More Related Videos

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System
10:36

Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System

Published on: June 12, 2015

8.2K

Related Experiment Videos

Last Updated: Oct 31, 2025

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications
09:08

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

12.7K
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System
10:36

Prescribed 3-D Direct Writing of Suspended Micron/Sub-micron Scale Fiber Structures via a Robotic Dispensing System

Published on: June 12, 2015

8.2K

Area of Science:

  • Biomedical Engineering
  • Microsystems Engineering
  • Drug Delivery Systems

Background:

  • Accurate and controlled drug delivery is crucial for therapeutic efficacy, especially in sensitive areas like the inner ear.
  • Existing drug delivery methods can be invasive or lack precise control, necessitating advanced microsystem solutions.

Purpose of the Study:

  • To develop and validate a wirelessly controlled, 3D-printed microsystem for precise drug delivery.
  • To assess the feasibility of long-term subcutaneous implantation and in vivo drug delivery efficacy.

Main Methods:

  • Fabrication of a microsystem using stereolithography 3D printing and inkjet printing, incorporating a refillable microreservoir and a phase-change peristaltic micropump.
  • Optimization of the microsystem for murine inner ear drug delivery (19 × 13 × 3 mm³).
  • In vivo evaluation through subcutaneous implantation in mice for six months and drug infusion into the round window membrane niche.

Main Results:

  • Benchtop testing confirmed reliable drug delivery performance.
  • Successful six-month subcutaneous implantation in mice demonstrated device biocompatibility and suitability for long-term use.
  • In vivo drug delivery using the microsystem yielded comparable results to traditional syringe pumps, as evidenced by otoacoustic emission measurements.

Conclusions:

  • The developed 3D-printed, wirelessly controlled microsystem offers a low-cost, scalable solution for precise drug delivery.
  • This technology holds potential for various clinical applications and delivery sites in both animal models and humans.
  • The microsystem's design facilitates efficient and controlled administration of therapeutics, particularly in otological applications.