From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models
Laura Joseph1, Thomas Merciecca1, Christiane Forestier1
1Laboratoire Microorganismes: Génome et Environnement, Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, France.
Abstract:
Klebsiella pneumoniae is a Gram-negative pathogen responsible for community-acquired and nosocomial infections. The strains of this species belong to the opportunistic group, which is comprised of the multidrug-resistant strains, or the hypervirulent group, depending on their accessory genome, which determines bacterial pathogenicity and the host immune response. The aim of this survey is to present an overview of the murine models mimicking K. pneumoniae infectious processes (i.e., gastrointestinal colonization, urinary, pulmonary, and systemic infections), and the bacterial functions deployed to colonize and disseminate into the host. These in vivo approaches are pivotal to develop new therapeutics to limit K. pneumoniae infections via a modulation of the immune responses and/or microbiota.
Insights
This study reviews mouse models for Klebsiella pneumoniae infections, including gastrointestinal, urinary, pulmonary, and systemic models. These models are crucial for developing new therapeutics targeting K. pneumoniae by modulating immune responses and microbiota.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Klebsiella pneumoniae is a Gram-negative pathogen causing community-acquired and nosocomial infections.
- Strains vary from opportunistic (multidrug-resistant) to hypervirulent, influenced by accessory genome.
- Bacterial pathogenicity and host immune response are determined by the accessory genome.
Purpose of the Study:
- To provide an overview of murine models for K. pneumoniae infectious processes.
- To examine bacterial functions in host colonization and dissemination.
- To highlight the importance of in vivo models for therapeutic development.
Main Methods:
- Review of existing literature on murine models for K. pneumoniae.
- Analysis of K. pneumoniae infection sites: gastrointestinal, urinary, pulmonary, and systemic.
- Examination of bacterial virulence factors and host-pathogen interactions.
Main Results:
- Murine models effectively mimic various K. pneumoniae infection types.
- Understanding bacterial colonization and dissemination mechanisms is key.
- These models are essential for evaluating novel therapeutic strategies.
Conclusions:
- In vivo murine models are pivotal for studying K. pneumoniae pathogenesis.
- Therapeutic development can be advanced by modulating host immune responses and microbiota.
- Further research using these models will aid in combating K. pneumoniae infections.
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