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Updated: Oct 30, 2025
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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
Published on: September 1, 2022
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Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording.
Saeyeong Jeon1, Youjin Lee2,3, Daeho Ryu1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Korea.
Micromachines
|July 2, 2021
Summary
Researchers developed a novel optrode array combining optogenetics and electrophysiology for precise neural control and recording. This new device enables effective optical activation and simultaneous neural activity monitoring in vivo.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optogenetics
Background:
- Optogenetics enables cell-type-specific neuromodulation, a crucial technique in neuroscience.
- Technological advancements in light delivery are enhancing optogenetic applications.
- Integrating optogenetics with electrophysiology offers synergistic benefits for neural research.
Purpose of the Study:
- To propose and characterize a novel optrode array design.
- To integrate optical modulation and electrophysiological recording capabilities.
- To validate the device's performance in vivo.
Main Methods:
- A 4x4 optrode array combined with five-channel recording electrodes was designed as a disposable component.
- A reusable component integrated an LED light source and power line.
- Light intensity at fiber tips was characterized.
- In vivo experiments were conducted using transgenic mice expressing channelrhodopsin.
Main Results:
- The optrode array successfully integrated optical stimulation and electrophysiological recording.
- Characterization confirmed light delivery intensity at fiber tips.
- In vivo experiments demonstrated effective optical activation of neurons.
- Simultaneous neural recording confirmed the device's functionality.
Conclusions:
- The novel optrode array design effectively combines optogenetics and electrophysiology.
- The device facilitates precise optical control and simultaneous neural recording.
- This integrated approach advances neuroscience research capabilities.
