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Selenite Substituted Calcium Phosphates: Preparation, Characterization, and Cytotoxic Activity.

Antonia Ressler1, Maja Antunović1, Matija Cvetnić1

  • 1Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, p.p.177, HR-10001 Zagreb, Croatia.

Materials (Basel, Switzerland)
|July 2, 2021
PubMed
Summary

Biomimetic calcium phosphate (CaP) systems were developed with selenite ions for osteosarcoma therapy. A specific formulation demonstrated selective toxicity to cancer cells, showing promise for targeted treatment.

Keywords:
biomaterialshydroxyapatiteionic substitutionsoctacalcium phosphateosteosarcomaselenite

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Materials Chemistry

Background:

  • Osteosarcoma therapy requires novel biomaterials with targeted efficacy.
  • Calcium phosphate (CaP) systems offer a versatile platform for drug delivery and therapeutic applications.
  • Selenium-containing compounds have shown potential in cancer treatment.

Purpose of the Study:

  • To prepare and characterize biomimetic selenium-substituted calcium phosphate (CaP) systems.
  • To evaluate the potential of these systems in osteosarcoma therapy.
  • To investigate the effect of selenite ion doping on CaP properties and cellular activity.

Main Methods:

  • Wet precipitation method using biogenic CaCO3, urea-H3PO4, and Na2SeO3·5H2O.
  • Characterization techniques included FTIR, elemental analysis, SEM, XRD, and Rietveld refinement.
  • In vitro studies involved incubation in simulated body fluid and cytotoxicity/viability tests on healthy and osteosarcoma cell lines.

Main Results:

  • Prepared powders consisted of calcium-deficient carbonated hydroxyapatite (HAp), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP).
  • Presence of Sr2+, Na+, and Mg2+ ions from cuttlefish bone precursor.
  • Selenite doping enhanced HAp thermal stability, and a powder with Se/(P + Se) molar ratio of 0.007 exhibited selective toxicity to cancer cells.

Conclusions:

  • Biomimetic selenium-substituted CaP systems can be successfully prepared.
  • These materials show potential for targeted osteosarcoma therapy due to selective cancer cell toxicity.
  • Further research is warranted to optimize these materials for clinical applications.