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3D Printing-A "Touch-Button" Approach to Manufacture Microneedles for Transdermal Drug Delivery
Merima Sirbubalo1, Amina Tucak1, Kenan Muhamedagic2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina.
Pharmaceutics
|July 2, 2021
Summary
Additive manufacturing (AM), or 3D printing, offers a fast and cost-effective method for creating microneedles (MNs). This technology enables personalized transdermal drug delivery systems with customizable designs and properties.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmaceutical Sciences
Background:
- Microneedles (MNs) are minimally invasive devices for transdermal drug delivery.
- Traditional MN manufacturing is often time-consuming and expensive, hindering rapid design iteration.
Purpose of the Study:
- To review 3D printing technologies for fabricating microneedles.
- To analyze the benefits, drawbacks, and applications of 3D printed MNs for transdermal drug delivery.
- To discuss mechanical properties, regulatory aspects, and evaluation methods for 3D printed MNs.
Main Methods:
- Literature review of additive manufacturing (AM) techniques for microneedle production.
- Analysis of research on 3D printed microneedle-assisted transdermal drug delivery systems.
- Examination of factors influencing mechanical properties and evaluation methodologies.
Main Results:
- Additive manufacturing enables rapid, cost-effective, and customizable production of microneedles.
- Various 3D printing technologies can fabricate microneedles from digital models in a single step.
- Research highlights the potential of 3D printed MNs for personalized transdermal drug delivery.
Conclusions:
- 3D printing revolutionizes microneedle fabrication, offering advantages over traditional methods.
- Further research and regulatory frameworks are essential for the clinical translation of 3D printed microneedles.
- Additive manufacturing facilitates the development of advanced transdermal drug delivery systems.
