Related Experiment Video
Updated: Jun 30, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Sweeteners in Orodispersible Films: How Much is too Much?
Ognjenka Rahić1, Sabina Behrem1, Amina Tucak-Smajić1
1University of Sarajevo - Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina.
Natural sweeteners like sucrose, xylitol, fructose, and isomalt significantly impact orodispersible film properties. Sweetener type and amount influence disintegration time, pH, and overall film characteristics for pharmaceutical applications.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Orodispersible films offer convenient drug delivery.
- Natural sweeteners are explored as excipients in oral dosage forms.
Purpose of the Study:
- To investigate the impact of four natural sweeteners (sucrose, xylitol, fructose, isomalt) on orodispersible film characteristics.
- To evaluate the influence of sweetener type and concentration on film properties.
Main Methods:
- Solvent casting method used for film preparation.
- Films formulated with Sodium carboxymethylcellulose and glycerol.
- Physicochemical, optical, and Fourier-transform infrared (FTIR) analyses performed.
Main Results:
- All films showed acceptable disintegration time, mass uniformity, thickness, and optical properties.
- Sweetener type and quantity significantly affected film characteristics (p<0.05).
- Films maintained a safe pH range for oral administration, confirmed by FTIR analysis.
Conclusions:
- Natural sweeteners can be successfully incorporated into orodispersible films.
- Sweetener selection and concentration are critical for optimizing film performance.
- The developed films are suitable for pharmaceutical applications due to their properties and safety profile.
More Related Videos
10:44Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
Published on: August 12, 2015
04:28Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
Published on: March 23, 2016
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Precipitation Titration Curve: Analysis
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry