Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced Liver Fibrosis Test, FIB-4 and FibroScan: Real-World Prognostic Accuracy for MASLD in a Biopsy-Controlled Cohort.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Predictors and Clinical Impact of Positive Blood Cultures in Emergency Department Patients with Suspected Infection.

Medicina (Kaunas, Lithuania)·2026
Same author

From gene detection to resistome ecology: targeted hybrid capture in AMR surveillance.

mSphere·2026
Same author

Characterization of the Effect of α-Lipoic Acid in Human Macrophages Infected with <i>Mycobacterium tuberculosis</i>.

International journal of molecular sciences·2026
Same author

The use of debridement, antibiotic pearls, and implant retention (DAPRI) in the management of acute periprosthetic joint infections: a systematic review.

Journal of bone and joint infection·2026
Same author

Protocol for determining minimum inhibitory concentrations of essential oils against bacterial pathogens using broth microdilution.

STAR protocols·2026

Related Experiment Video

Updated: Oct 30, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

13.9K

Post-Prescription Audit Plus Beta-D-Glucan Assessment Decrease Echinocandin Use in People with Suspected Invasive

Rita Murri1,2, Sara Lardo3, Alessio De Luca4

  • 1Department of Laboratory and Infectious Diseases Sciences, A. Gemelli University Hospital Foundation IRCCS, 00168 Rome, Italy.

Medicina (Kaunas, Lithuania)
|July 2, 2021
PubMed
Summary
This summary is machine-generated.

Antifungal stewardship programs can reduce echinocandin use in suspected invasive candidiasis. Combining post-prescription audits with beta-D-glucan (BDG) testing effectively shortens antifungal treatment duration.

Keywords:
Candida bloodstream infectionantifungal stewardshipechinocandin

More Related Videos

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

3.3K
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.4K

Related Experiment Videos

Last Updated: Oct 30, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

13.9K
A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

3.3K
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.4K

Area of Science:

  • Infectious Diseases
  • Clinical Pharmacy
  • Medical Microbiology

Background:

  • Overtreatment with antifungal medications is a significant clinical concern.
  • Antifungal stewardship (AFS) aims to optimize therapy for invasive fungal infections.
  • Reducing unnecessary antifungal exposure is crucial for patient outcomes and resource management.

Purpose of the Study:

  • To assess the effectiveness of a post-prescription audit combined with beta-D-glucan (BDG) testing in reducing echinocandin use.
  • To evaluate the impact of this intervention on the duration of antifungal therapy for suspected invasive candidiasis.

Main Methods:

  • A prospective, pre-post quasi-experimental study design was employed.
  • The intervention involved reviewing echinocandin prescriptions and utilizing BDG results to guide discontinuation.
  • Data from the pre-intervention phase were compared to the intervention phase.

Main Results:

  • Antifungal therapy was discontinued in 48.8% of patients during the intervention phase.
  • The duration of echinocandin therapy was significantly reduced in the intervention group (4.1 days) compared to the pre-intervention group (7.4 days).
  • No significant differences were observed in length of hospital stay or mortality between the groups.

Conclusions:

  • A combined approach of pre-prescription restriction and post-prescription audit with BDG measurement effectively optimizes antifungal therapy.
  • This strategy significantly reduces excessive treatment durations for echinocandins in suspected invasive candidiasis.
  • The findings support the integration of BDG testing into antifungal stewardship protocols.