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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Related Experiment Video

Updated: Oct 30, 2025

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3D Printing of Dapagliflozin Containing Self-Nanoemulsifying Tablets: Formulation Design and In Vitro

Mohammed S Algahtani1, Abdul Aleem Mohammed1, Javed Ahmad1

  • 1Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.

Pharmaceutics
|July 2, 2021
PubMed
Summary

This study demonstrates 3D printing of a self-nanoemulsifying tablet for dapagliflozin, a poorly soluble drug. The novel formulation ensures rapid drug release, enhancing oral delivery of nanomedicines.

Keywords:
SEM-EDS analysisdapagliflozin propanediol monohydratedrug dissolutionnanoemulsionself-nanoemulsifying tabletsemisolid extrusion-based 3D printing

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Area of Science:

  • Pharmaceutical Technology
  • Nanomedicine
  • 3D Printing Applications

Background:

  • 3D printing offers advanced pharmaceutical manufacturing and drug delivery solutions.
  • Developing effective oral solid dosage forms for poorly water-soluble drugs remains a challenge.

Purpose of the Study:

  • To design and develop a nanomedicine-based oral solid dosage form for dapagliflozin using 3D printing.
  • To create a self-nanoemulsifying tablet formulation for improved drug solubility and release.

Main Methods:

  • Utilized semisolid pressure-assisted microsyringe (PAM) extrusion-based 3D printing.
  • Formulated a self-nanoemulsifying system with specific oils, co-surfactants, surfactant, and solid matrix excipients.
  • Characterized the nanoemulsion droplet size, drug-excipient interactions (FT-IR), drug dispersion (DSC, X-RD), and encapsulation (SEM, SEM-EDS).

Main Results:

  • Successfully fabricated 3D printed self-nanoemulsifying tablets of dapagliflozin propanediol monohydrate.
  • Achieved nanoemulsion droplet size of 104.7 ± 3.36 nm with a PDI of 0.063 ± 0.024.
  • Demonstrated molecular dispersion of dapagliflozin, complete encapsulation, and an immediate-release profile (>75% release within 20 min).

Conclusions:

  • The PAM-based 3D printing technique is effective for producing self-nanoemulsifying tablets.
  • This approach enhances the delivery of poorly water-soluble drugs like dapagliflozin.
  • The developed dosage form offers an immediate-release profile suitable for oral administration.