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Extrusion-based 3D printing for development of complex capsular systems for advanced drug delivery
Mohammed S Algahtani1, Javed Ahmad1, Abdul Aleem Mohammed1
1Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia.
International Journal of Pharmaceutics
|August 5, 2024
Summary
Extrusion-based 3D printing, including Fused Deposition Modelling (FDM) and Pressure-Assisted Modelling (PAM), enables complex drug delivery systems. This technology allows for customized dosage forms for controlled and targeted drug release, improving patient outcomes.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biomedical Engineering
Background:
- Traditional drug delivery systems face limitations in achieving precise control over drug release kinetics and targeted delivery.
- 3D printing offers a novel approach to overcome these limitations by enabling the fabrication of intricate dosage forms.
- Extrusion-based 3D printing techniques, specifically Fused Deposition Modelling (FDM) and Pressure-Assisted Modelling (PAM), are emerging as powerful tools in pharmaceutical manufacturing.
Purpose of the Study:
- To review the feasibility of extrusion-based 3D printing for creating complex drug delivery systems.
- To explore the potential of FDM and PAM in fabricating customized capsular dosage forms for controlled drug release.
- To discuss the impact of 3D printed dosage form design on biopharmaceutical performance and specialized delivery applications.
Main Methods:
- Review of current literature on extrusion-based 3D printing techniques in pharmaceutical applications.
- Analysis of Fused Deposition Modelling (FDM) and Pressure-Assisted Modelling (PAM) for fabricating complex dosage forms.
- Discussion of design parameters and their influence on drug release profiles and therapeutic outcomes.
Main Results:
- Extrusion-based 3D printing allows for the creation of single-, dual-, or multi-compartment capsular systems with tailored geometries.
- Customized designs enable precise control over drug release, including delayed, sustained, and pulsatile patterns.
- The technology shows potential for various specialized drug delivery applications such as gastric floating systems, implants, suppositories, and printfills.
Conclusions:
- Extrusion-based 3D printing is a feasible technology for producing advanced, complex drug delivery systems.
- This approach offers significant advantages for achieving controlled and targeted drug delivery, enhancing therapeutic efficacy.
- 3D printing holds great promise for advancing personalized medicine and improving patient adherence to medication regimens.
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