Related Experiment Video

Updated: Oct 30, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

2.8K

The Roles of DNA Demethylases in Triple-Negative Breast Cancer

Shoghag Panjarian1, Jean-Pierre J Issa1

  • 1Coriell Institute Research Department, Coriell Institute for Medical Research, Camden, NJ 08103, USA.

Pharmaceuticals (Basel, Switzerland)
|July 2, 2021
PubMed

Insights

Triple-negative breast cancer (TNBC) is a diverse subtype with a high risk of metastasis. TET1 may play an oncogenic role in TNBC, offering potential new therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Triple-negative breast cancer (TNBC) is molecularly diverse and prone to relapse and metastasis.
  • TNBC is diagnosed by the absence of Estrogen Receptor (ER), Progesterone Receptor (PR), and HER2.
  • Distinct DNA methylation profiles, including hypomethylation, characterize TNBCs.

Purpose of the Study:

  • To review the dual role of ten-eleven translocation (TET) enzymes as tumor suppressors or oncogenes in solid tumors.
  • To discuss the oncogenic role of TET1 in TNBC.
  • To explore the therapeutic implications of TET1 in TNBC.

Main Methods:

  • Literature review of TET enzyme functions in solid tumors.
  • Analysis of existing research on DNA methylation in TNBC.
  • Discussion of TET1's specific role and therapeutic potential in TNBC.

Main Results:

  • TET enzymes exhibit context-dependent roles as tumor suppressors or oncogenes.
  • TET1 is implicated in the oncogenesis of TNBC.
  • Understanding TET1's function provides insights into potential therapeutic strategies for TNBC.

Conclusions:

  • TET enzymes are critical regulators of DNA methylation with diverse roles in cancer.
  • TET1's oncogenic function in TNBC presents a promising avenue for targeted therapies.
  • Further research into TET1 is crucial for developing novel treatments for triple-negative breast cancer.
Keywords:
DNA methylationTET enzymeTNBC

More Related Videos

Methyl-binding DNA capture Sequencing for Patient Tissues08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

8.8K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

9.9K

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.8K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.9K