Related Experiment Video

Updated: Oct 30, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

75

Mutual Correlation between Non-Coding RNA and S-Adenosylmethionine in Human Cancer: Roles and Therapeutic

Laura Mosca1, Francesca Vitiello1, Luigi Borzacchiello1

  • 1Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Cancers
|July 2, 2021
PubMed

Insights

Investigating the interplay between S-adenosylmethionine (AdoMet) and non-coding RNAs (ncRNAs) in cancer epigenetics offers new therapeutic strategies. Understanding these epigenetic modulators can lead to more effective anticancer treatments.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • Epigenetics involves DNA methylation, histone modifications, and non-coding RNA (ncRNA) expression.
  • S-adenosylmethionine (AdoMet) is the universal methyl donor for epigenetic reactions.
  • Dysregulation of ncRNAs, like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is implicated in human cancers.

Purpose of the Study:

  • To explore the intricate relationships between AdoMet and ncRNAs in the context of human cancer.
  • To provide insights into developing novel and more effective anticancer therapeutic approaches.
  • To summarize recent findings on the bioactivity mechanisms of AdoMet and ncRNAs.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of the complex network of interconnections between AdoMet and ncRNAs.
  • Examination of how ncRNAs and AdoMet influence epigenetic mechanisms.

Main Results:

  • A complex network of mutual interconnections exists between AdoMet and ncRNAs.
  • ncRNA expression can be regulated by epigenetic mechanisms like DNA and RNA methylation.
  • ncRNAs can modulate the expression of epigenetic enzymatic components at the post-transcriptional level.

Conclusions:

  • Understanding the interplay between AdoMet, ncRNAs, and epigenetic modifications is crucial for cancer research.
  • These interactions offer potential for developing innovative and efficient anticancer strategies.
  • Targeting these epigenetic modulators may lead to new therapeutic avenues for cancer treatment.
Keywords:
S-adenosylmethioninecancer therapyepigeneticslong non-coding RNAmicroRNAnon-coding RNA

More Related Videos

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.1K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.6K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.6K
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
293
RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.3K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
34.3K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
69.9K