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Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical
Alexander Malogolovkin1, Nizami Gasanov1, Alexander Egorov1
1Gene Therapy Department, Sirius University of Science and Technology, Olympic Avenue, 1, 354340 Sochi, Russia.
Viruses
|July 2, 2021
Summary
Cancer immunotherapy, including immune checkpoint inhibitors (ICI) and oncolytic viruses, offers new hope. This review highlights effective combinations of oncolytic viruses with other therapies for cancer treatment.
Area of Science:
- Oncology
- Immunotherapy
- Virology
Background:
- Cancer immunotherapy has advanced significantly, with immune checkpoint inhibitors (ICI) becoming crucial in treating various cancers.
- Oncolytic viruses are emerging as a promising therapeutic strategy, showing encouraging results in clinical trials.
- Combining oncolytic viruses with conventional treatments like chemotherapy and radiotherapy is under extensive investigation.
Purpose of the Study:
- To review clinical trial data on oncolytic viruses, focusing on their efficacy and safety.
- To identify and highlight the most promising combinations of oncolytic viruses with other immunotherapies and treatments.
- To provide insights into future strategies for cancer treatment using virus immunotherapy.
Main Methods:
- Systematic review of published clinical trial data on oncolytic virus therapy.
- Analysis of combinations involving oncolytic viruses with immune checkpoint blockade, cytokines, antigens, and other oncolytic viruses.
- Evaluation of efficacy and safety data from clinical studies.
Main Results:
- Oncolytic viruses, with or without genetic modifications, show potential when combined with immune checkpoint blockade and other agents.
- Several combinations are demonstrating encouraging outcomes in clinical settings.
- The review focuses on published clinical data to identify effective therapeutic strategies.
Conclusions:
- Virotherapy, particularly in combination with other immunotherapies, represents a significant advancement in cancer treatment.
- Further research into optimizing oncolytic virus combinations is essential for maximizing therapeutic benefits.
- Future perspectives suggest novel strategies for cancer treatment through advanced virus immunotherapy.
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