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Fungal Infections in Liver Transplant Recipients

Michael Scolarici1, Margaret Jorgenson2, Christopher Saddler1

  • 1Department of Medicine, University of Wisconsin, Madison, WI 53792, USA.

Journal of Fungi (Basel, Switzerland)
|July 2, 2021
PubMed

Insights

Invasive fungal infections (IFIs) pose significant risks after liver transplantation. Prophylaxis strategies are crucial for preventing these serious infections and improving patient outcomes.

Area of Science:

  • * Medical Mycology
  • * Transplantation Medicine
  • * Infectious Diseases

Background:

  • * Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in liver transplant recipients.
  • * Common IFIs include Candida, Aspergillus, and Cryptococcal infections, alongside rarer but severe mold infections.

Purpose of the Study:

  • * To review common and less frequent invasive fungal infections in liver transplant patients.
  • * To evaluate the role of antifungal prophylaxis in mitigating IFIs post-transplant.

Main Methods:

  • * Literature review and synthesis of existing data on IFIs in liver transplantation.
  • * Analysis of current prophylaxis strategies and their effectiveness.

Main Results:

  • * Candida, Aspergillus, and Cryptococcal species are the most prevalent fungal pathogens.
  • * Certain mold infections present a significant, albeit less frequent, threat.
  • * Antifungal prophylaxis shows promise in reducing IFI incidence.

Conclusions:

  • * IFIs represent a critical challenge in liver transplant care.
  • * Prophylactic antifungal administration is a key strategy to improve patient safety and reduce IFI-related complications.
Keywords:
Aspergilluscandidiasiscryptococcosisinvasive fungal infectionliver transplant

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