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Right and left ventricular function during chronic amiodarone therapy.

R S Sheldon1, L B Mitchell, H J Duff

  • 1Department of Medicine, University of Calgary, Canada.

The American Journal of Cardiology
|October 1, 1988
PubMed
Summary
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Chronic amiodarone therapy effectively suppresses ventricular tachycardia without negatively impacting ventricular function, including ejection fraction and wall motion, in patients. Long-term use demonstrates sustained ventricular performance, even in those with pre-existing reduced function.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Chronic amiodarone therapy is a key treatment for ventricular tachycardia.
  • Long-term effects of amiodarone on ventricular function require evaluation.

Purpose of the Study:

  • To assess the impact of chronic amiodarone therapy on left ventricular (LV) and right ventricular (RV) ejection fraction (EF) and wall motion in patients with ventricular tachycardia.

Main Methods:

  • Evaluated 21 patients with ventricular tachycardia before and at 2, 6, 10, and 20 weeks of amiodarone therapy.
  • Measured LV and RV ejection fraction (EF) and wall motion scores.
  • Monitored serum amiodarone levels throughout the study.

Main Results:

  • Amiodarone therapy did not significantly alter mean LVEF or RVEF at any time point.

Related Experiment Videos

  • No significant changes in LV or RV wall motion scores were observed during therapy.
  • Ventricular function remained stable in patients with pre-existing reduced LVEF (<40%) and in those followed for up to 34 months.

    • Conclusions:

    • Chronic amiodarone therapy for ventricular tachycardia does not adversely affect systolic ventricular function.
    • Sustained ventricular performance is maintained during long-term amiodarone treatment.