Clinicopathological Correlations in Cutaneous Squamous Cell Carcinomas.

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Squamous cell carcinoma (SCC) is a common nonmelanoma skin cancer.
• Most SCC cases respond well to conventional treatments.
• Accurate diagnosis and prognosis are crucial for effective management.

Purpose of the Study:

• To analyze clinical and histopathological factors associated with SCC aggressiveness.
• To determine the correlation between tumor grade, pT category, and prognostic indicators in SCC.

Main Methods:

• A retrospective study of 103 SCC cases.
• Assessment of clinical and histopathological aggressivity factors.
• Digital storage and statistical analysis using comparison tests.

Main Results:

• Tumor grade significantly correlated with histological variant, tumor size, perineural/lymphovascular invasion, invasion depth, and resection margins.
• pT category associated with tumor location, size, perineural invasion, invasion depth, and resection margins.
• A significant association was found between tumor grade and pT category.

Conclusions:

• Evaluating SCC's clinical and histological characteristics provides vital prognostic information.
• This evaluation aids in selecting appropriate therapeutic strategies for SCC patients.