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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
Hyeon Seok Hwang1, Jin Sug Kim1, Yang Gyun Kim1
1Division of Nephrology, Department of Internal Medicine, KyungHee University, Seoul, South Korea.
Frontiers in Cardiovascular Medicine
|July 2, 2021
Summary
Higher neprilysin levels in hemodialysis patients predict cardiovascular and cardiac events. This suggests neprilysin inhibition may reduce these risks in this population.
Area of Science:
- Cardiology
- Nephrology
- Biomarker Research
Background:
- Neprilysin inhibition shows promise in heart failure.
- The role of neprilysin as a cardiovascular biomarker in hemodialysis patients is not well understood.
Purpose of the Study:
- To investigate the association between circulating neprilysin levels and cardiovascular (CV) events in hemodialysis (HD) patients.
- To determine if neprilysin can serve as a predictive biomarker for CV and cardiac events in HD patients.
Main Methods:
- 439 hemodialysis patients were enrolled in the K-cohort study.
- Plasma neprilysin levels and echocardiographic data were analyzed at baseline.
- Patients were prospectively followed for composite CV and cardiac events.
Main Results:
- Plasma neprilysin correlated positively with left ventricular mass and volumes, and negatively with ejection fraction.
- Higher neprilysin levels (tertile 3) were associated with increased cumulative rates of CV and cardiac events.
- Cox regression showed neprilysin tertile 3 significantly increased the risk for composite CV events (2.61-fold) and cardiac events (2.72-fold).
Conclusions:
- Elevated circulating neprilysin independently predicts composite CV and cardiac events in hemodialysis patients.
- These findings highlight neprilysin as a potential therapeutic target for reducing CV risk in HD patients.
- Further research into neprilysin inhibition for CV event reduction in HD is warranted.
Keywords:
atherosclerosiscardiovascular diseasehemodialysisleft ventricular systolic dysfunctionneprilysinMore Related Videos
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