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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

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Published on: September 2, 2015

Flexible Ultrasonic Patch for Accelerating Chronic Wound Healing.

Wenhan Lyu^1,2, Yinji Ma^1,2, Siyu Chen^1,2

¹AML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China.

Advanced Healthcare Materials

|July 2, 2021

Summary

This study introduces a flexible ultrasonic patch for chronic wound healing, improving treatment effectiveness and reducing infection risk. The novel patch accelerates healing by approximately 40% in diabetic rats.

Keywords:

chronic wounds flexible ultrasonic patches wound treatments

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Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Published on: May 8, 2012

Area of Science:

Biomedical Engineering
Regenerative Medicine
Wound Healing Technologies

Background:

Ultrasound therapy accelerates chronic wound healing but faces limitations due to non-conformal probes and infection risks from liquid coupling agents.
Traditional ultrasound probes lack flexibility, hindering consistent contact with wound surfaces and leading to variable treatment outcomes.
The need for improved wound healing modalities, especially for chronic conditions like diabetic ulcers, is critical.

Purpose of the Study:

To design and fabricate a flexible ultrasonic patch for effective and safe chronic wound treatment.
To overcome the limitations of traditional ultrasonic probes, including poor conformability and infection risks.
To investigate the mechanism of ultrasound-accelerated wound healing and its efficacy in a preclinical model.

Main Methods:

Fabrication of a flexible ultrasonic patch using discretized piezoelectric ceramic units on a flexible circuit substrate.
Integration of a hydrogel layer for encapsulation, coupling, and infection prevention.
Evaluation of the patch's conformability, sound beam focusing capabilities, and therapeutic effect in type-II diabetic rat models.

Main Results:

The flexible ultrasonic patch demonstrated excellent conformability to wound surfaces.
Ultrasound treatment significantly accelerated wound healing, shortening healing time by approximately 40% in diabetic rats.
Immunohistochemical analysis revealed ultrasound activates Rac1 in dermal and epidermal layers, contributing to enhanced healing.

Conclusions:

The flexible ultrasonic patch offers a promising, safe, and effective approach for accelerating chronic wound healing.
This technology overcomes the limitations of conventional ultrasound probes, providing stable treatment effects and reducing infection risk.
Ultrasound's mechanism involves Rac1 activation, highlighting its potential in regenerative therapies for chronic wounds.